Scientific news

Multiplexed CRISPR base editing enables pulse-activated irreversible biocontainment of engineered bacteria Open Access

Multiplexed CRISPR base editing enables pulse-activated irreversible biocontainment of engineered bacteria Open Access

Wednesday, 20-05-2026 | 08:16

The environmental and therapeutic application of genetically engineered microorganisms necessitates the development of robust, irreversible biocontainment systems. In this study, we present an eEGM (editing-driven essential gene multiplex inactivation) module that utilizes CRISPR-mediated cytidine base editing to induce permanent self-killing via a single transient induction. By targeting the start codons of essential genes,

Discovery of cold tolerance genes and favorable alleles in Kam sweet rice across various growth stages

Discovery of cold tolerance genes and favorable alleles in Kam sweet rice across various growth stages

Integration of Ty-1/Ty-3 and Ty-6 confers improved and durable resistance to highly pathogenic begomoviruses in tomato

Integration of Ty-1/Ty-3 and Ty-6 confers improved and durable resistance to highly pathogenic begomoviruses in tomato

Integrated physiological, biochemical and hormonal traits determine drought tolerance and yield stability in cashew (Anacardium occidentale L.)

Integrated physiological, biochemical and hormonal traits determine drought tolerance and yield stability in cashew (Anacardium occidentale L.)

Advances and prospects of genomic-assisted breeding in roots, tubers, and banana crops

Advances and prospects of genomic-assisted breeding in roots, tubers, and banana crops

Unlocking genetic diversity in Colombian cassava landraces for accelerated breeding

Unlocking genetic diversity in Colombian cassava landraces for accelerated breeding

An auxin-induced transcriptional cascade CmBES1–CmSAUR66 orchestrates the ray floret development in Chrysanthemum morifolium

An auxin-induced transcriptional cascade CmBES1–CmSAUR66 orchestrates the ray floret development in Chrysanthemum morifolium

Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis

Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis

First brassinosteroid-based dwarf mutant discovered and characterized in grapevine

First brassinosteroid-based dwarf mutant discovered and characterized in grapevine

ZmWAK3 overexpression enhances cold tolerance via coordinated improvement of antioxidant defense and photosynthesis

ZmWAK3 overexpression enhances cold tolerance via coordinated improvement of antioxidant defense and photosynthesis

Resistance gene against Xanthomonas oryzae pv. oryzae (Xoo) in rice: molecular mechanisms and breeding strategies for bacterial leaf blight

Resistance gene against Xanthomonas oryzae pv. oryzae (Xoo) in rice: molecular mechanisms and breeding strategies for bacterial leaf blight

Emergence of Bacterial Leaf Blight of Rice in Madagascar: A Recent Introduction from Asia

Emergence of Bacterial Leaf Blight of Rice in Madagascar: A Recent Introduction from Asia

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