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Thursday, 17-09-2020 | 08:48
Cytosolic calcium enters the mitochondrial matrix through the mitochondrial calcium uniporter (MCU) where it acts as a signal that regulates ATP production (1), metabolic fuel selection (1⇓–3), and if excessively high, triggers cell death (4). The complete complex of the MCU subunits is now referred to as the mitochondrial calcium uniporter holocomplex (MCUcx) (5). In PNAS, Vais et al. (6) focus on how the levels of Ca2+ inside the mitochondrial matrix ([Ca2+]m) can regulate the MCUcx itself.
