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At the dawn of the new One CGIAR era, what is the clarion call to the CGIAR networks and partners? In my opinion, CGIAR needs to pick big, inspiring, and important questions to answer. Can there be a bigger question for humanity than how to ensure access to a healthy diet for all? Currently, three billion people do not have such access (SOFI 2020). One billion of them live in Africa, accounting for 74% of the continent’s population. This situation threatens to get worse before it gets better: study after study shows that the prices of nutritious foods are increasing relative to the prices of staples.