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A miniature alternative to Cas9 and Cas12: Transposon-associated TnpB mediates targeted genome editing in plants
A miniature alternative to Cas9 and Cas12: Transposon-associated TnpB mediates targeted genome editing in plants
Friday, 02-08-2024 | 08:23

The two popular genome editor nucleases, Cas9 and Cas12a, hypothetically evolved from IscB and TnpB, respectively (Altae-Tran et al., 2021). Recent reports showed that TnpBs also function as RNA-guided nucleases in human cells (Karvelis et al., 2021). TnpB proteins are much smaller (~400 aa) than Cas9 (~1000–1400 aa) and Cas12a (~1300 aa). The large cargo size of Cas9 and Cas12a hinders their delivery into cells, particularly through viral vectors

Introgression of blast and bacterial blight disease resistance genes in a rice genotype ADT43 through marker assisted back cross breeding
Introgression of blast and bacterial blight disease resistance genes in a rice genotype ADT43 through marker assisted back cross breeding
Pangenome-Wide Association Study and Transcriptome Analysis Reveal a Novel QTL and Candidate Genes Controlling both Panicle and Leaf Blast Resistance in Rice
Pangenome-Wide Association Study and Transcriptome Analysis Reveal a Novel QTL and Candidate Genes Controlling both Panicle and Leaf Blast Resistance in Rice
Polyploidy in maize: from evolution to breeding
Polyploidy in maize: from evolution to breeding
Genotyping-by-sequencing targets genic regions and improves resolution of genome-wide association studies in autotetraploid potato
Genotyping-by-sequencing targets genic regions and improves resolution of genome-wide association studies in autotetraploid potato
Novel SNP markers and other stress-related genomic regions associated with nitrogen use efficiency in cassava
Novel SNP markers and other stress-related genomic regions associated with nitrogen use efficiency in cassava
Transcriptomic study of the role of MeFtsZ2-1 in pigment accumulation in cassava leaves
Transcriptomic study of the role of MeFtsZ2-1 in pigment accumulation in cassava leaves
Natural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification
Natural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification
Safety of soy leghemoglobin from genetically modified Komagataella phaffii as a food additive
Safety of soy leghemoglobin from genetically modified Komagataella phaffii as a food additive
Cold tolerance SNPs and candidate gene mining in the soybean germination stage based on genome-wide association analysis
Cold tolerance SNPs and candidate gene mining in the soybean germination stage based on genome-wide association analysis
Trends and Evolution of Research on Genetic Modification: A Bibliometric Analysis of Scientific Literature During 2000-2020
Trends and Evolution of Research on Genetic Modification: A Bibliometric Analysis of Scientific Literature During 2000-2020
Genome-wide association studies dissect low-phosphorus stress response genes underling field and seedling traits in maize
Genome-wide association studies dissect low-phosphorus stress response genes underling field and seedling traits in maize

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