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Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
Saturday, 19-06-2021 | 07:09

The ongoing COVID-19 pandemic has caused an unprecedented global health crisis. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19. Subversion of host protein synthesis is a common strategy that pathogenic viruses use to replicate and propagate in their host. In this study, we show that SARS-CoV-2 is able to shut down host protein synthesis and that SARS-CoV-2 nonstructural protein NSP14 exerts this activity. We show that the translation inhibition activity of NSP14 is conserved in human coronaviruses. NSP14 is required for virus replication through contribution of its exoribonuclease (ExoN) and N7-methyltransferase (N7-MTase) activities.

TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis
TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis
High-throughput phenotyping of soybean genotypes under base saturation stress conditions
High-throughput phenotyping of soybean genotypes under base saturation stress conditions
Precise genome modification in tomato using an improved prime editing system
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Characterizing the “fungal shunt”: Parasitic fungi on diatoms affect carbon flow and bacterial communities in aquatic microbial food webs
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CRISPR-based targeting of DNA methylation in Arabidopsis thaliana by a bacterial CG-specific DNA methyltransferase
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Mapping of a QTL with major effect on reducing leaf rust severity at the adult plant growth stage on chromosome 2BL in wheat landrace Hongmazha
Mapping of a QTL with major effect on reducing leaf rust severity at the adult plant growth stage on chromosome 2BL in wheat landrace Hongmazha
Genome-wide identification and analysis of the sucrose synthase gene family in cassava (Manihot esculenta Crantz)
Genome-wide identification and analysis of the sucrose synthase gene family in cassava (Manihot esculenta Crantz)

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